Chinese skullcap is one such herb which is gaining attention among the researchers for its neuroprotective property. This page features 105 references. Zhongguo Zhong.Yao Za Zhi 2009;34(22):2910-2915. Cheng, K. T., Hou, W. C., Huang, Y. C., and Wang, L. F. Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Baikal skullcap might slow blood clotting. It is from there that the forefathers of Ancient Chinese medicine have plucked it for well over 1,000 years. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. 1998;61(1):37-39. Popular Vitamins & Supplements; Swanson Chinese Skullcap; Everyday Low Price. Lee, S. W., Song, G. S., Kwon, C. H., and Kim, Y. K. Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. J Ethnopharmacol. MedicineNet does not provide medical advice, diagnosis or treatment. Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. View abstract. View abstract. 2009;30(11):1505-1512. September 2012. Baikal skullcap might have an effect like a water pill or "diuretic." J Chromatogr.A 3-19-2010;1217(12):1875-1881. Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. 105 unique references to scientific papers. Advertisement. View abstract. View abstract. Our evidence-based analysis on scutellaria baicalensis features Are there any interactions with medications? Eksp.Klin Farmakol. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. This could increase how much lithium is in the body and result in serious side effects. Protective effect of baicalein extracted from Scutellaria baicalensis against lipopolysaccharide-induced glomerulonephritis in mice. Maybe. J Ethnopharmacol. 1998;61(2):54-56. 2009;48(12):1159-1169. 2007;42(10):1074-1077. View abstract. View abstract. Jeong, K., Shin, Y. C., Park, S., Park, J. S., Kim, N., Um, J. Y., Go, H., Sun, S., Lee, S., Park, W., Choi, Y., Song, Y., Kim, G., Jeon, C., Park, J., Lee, K., Bang, O., and Ko, S. G. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. Chem Pharm Bull (Tokyo) 2004;52(10):1162-1165. Chinese Journal of Gerontology 2010;30(7):926-928. In other words, it enhances the value of other herbs, especially those with antimicrobial value. In fact, when an ancient Chinese Tomb was discovered in 1973, tablets were unearthed inside which purported the many healing powers of Huang Qin. Eksp.Klin Farmakol. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. Chen, S., Yuan, Y., Luo, Y., Huang, L., Chen, P., and Li, X. An intravenous preparation that includes Baikal skullcap, forsythia, and honeysuckle has been used under medical supervision with apparent safety in children for up to 7 days. View abstract. Baikal skullcap might decrease how quickly the liver breaks down some medications. View abstract. Low blood pressure: Baikal skullcap might lower blood pressure. Try Sori Yanagi Stainless Steel. View abstract. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. Sheng, J. P., Chen, H. R., and Shen, L. [Determination of six mineral elements in roots, stems, leaves, flowers and seeds of Scutellaria baicalensis by FAAS]. All factual claims are Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. View abstract. Zhou, X., Zhang, Q., Liang, H., Jiang, Y., Wang, X., Wang, B., and Zhao, Y. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. View abstract. Some medications are changed and broken down by the liver. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. S. baicalensis, also known as Huang Qin or Chinese skullcap, is a root extract used in traditional medicine.It is often used in combination with other herbs. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. View abstract. View abstract. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. The root is used to make medicine. View abstract. Chen, H. H., Hong, H. J., Chou, Y. H., Cheng, T. H., Chen, J. J., and Lin, H. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. View abstract. Scutellaria baicalensis (Chinese Skullcap) is a traditional chinese medicine for the purposes of cardiovascular and cognitive health as well as longevity. View abstract. Ann Intern Med 2012;156:894-5. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. As it was named after a covering, it isn't suprising that skullcap is often used as a herbal remedy to protect against rabies symptoms and relieve tension, lower blood pressure and more. It is also used for gastrointestinal (GI) infections, as well as liver problems including viral hepatitis and jaundice. Trustpilot. 2004;91(1):65-68. Razina, T. G., Udintsev, S. N., Prishchep, T. P., and Iaremenko, K. V. [Enhancement of the selectivity of the action of the cytostatics cyclophosphane and 5-fluorouracil by using an extract of the Baikal skullcap in an experiment]. XI. J Ethnopharmacol. View abstract. Baikal skullcap was included as an ingredient in several pharmaceutical combination preparations found in a second century AD tomb in northwestern China. View abstract. PL Detail-Document, Liver Toxicity and Limbrel. View abstract. View abstract. 2011;31(4):1130-1132. Cancer Lett. Lee, Y. M., Cheng, P. Y., Chim, L. S., Kung, C. W., Ka, S. M., Chung, M. T., and Sheu, J. R. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Levy RM, Khokhlov A, Kopenkin S, et al. 2008;6(1):103-8. View abstract. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. View abstract. The skullcap herb is a plant that is used for medicinal purposes in both Chinese and American medicine. View abstract. Vestn.Ross.Akad.Med Nauk 1995;(1):29-38. Curr Neurol.Neurosci.Rep. View abstract. View abstract. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. The term skullcap typically refers to two specific plants from the Scutellaria genus: Scutellaria baicalensis (Chinese skullcap) and Scutellaria lateriflora (American skullcap). Krakauer, T., Li, B. Q., and Young, H. A. Ceska.Slov.Farm. Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. It is thought that the active chemicals in Baikal skullcap might be able to decrease inflammation, stop tumor growth, and prevent tumor cell reproduction. Levy RM, Saikovsky R, Shmidt E, et al. J Chromatogr.B Analyt.Technol Biomed.Life Sci 4-15-2011;879(13-14):1023-1028. Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. As with most ailments, rather than trying to mask or alleviate the symptoms, one … Hao, H., Aixia, Y., Dan, L., Lei, F., Nancai, Y., and Wen, S. Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis. View abstract. Takahashi, H., Chen, M. C., Pham, H., Angst, E., King, J. C., Park, J., Brovman, E. Y., Ishiguro, H., Harris, D. M., Reber, H. A., Hines, O. J., Gukovskaya, A. S., Go, V. L., and Eibl, G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Konoshima, T., Kokumai, M., Kozuka, M., Iinuma, M., Mizuno, M., Tanaka, T., Tokuda, H., Nishino, H., and Iwashima, A. Phytomedicine. Cheng, K. T., Huang, Y. C., Lin, Y. S., Su, B., and Chen, C. M. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. It appears to be a good source for flavonoid compounds, and some components are quite potent. View abstract. View abstract. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. Altern.Ther.Health Med. CNS.Neurol.Disord Drug Targets. View abstract. Beijing Da.Xue.Xue.Bao. Yim, J. S., Kim, Y. S., Moon, S. K., Cho, K. H., Bae, H. S., Kim, J. J., Park, E. K., and Kim, D. H. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. View abstract. Traditional Chinese Medicine uses Baikal skullcap (Scutellaria baicallensis) as one of their 50 fundamental herbs. Journal of medicinal food 2009;12(5):1143-8. A specific combination product called flavocoxid (Limbrel, Primus Pharmaceuticals) that contains Baikal skullcap was safely used in research studies lasting up to 12 weeks. Lei, W., Sun, M., Luo, K. M., Shui, X. R., Sun, Y. M., and Tang, H. [Compute simulation to characterize structure and function of chalcone synthase from Scutellaria baicalensis Georgi]. View abstract. [The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia]. Wu, J. View abstract. It is also used for scarlet fever, headache, irritability, red eyes, flushed face, seizures, epilepsy, hysteria, nervous tension, and to relieve a bitter taste in the mouth. View abstract. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Int Immunopharmacol. View abstract. Bleeding disorders. Our independent, unbiased approach reveals what works (and what's a waste of time and money). Z., Jing, X. L., Guo, X. H., and Zhu, Y. Y. By Swanson. Planta Med 2002;68(2):128-132. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others. Planta Med 2003;69(4):300-304. J Dermatol Sci 2007;46(1):31-40. Afr J Tradit Complement Altern Med. View abstract. Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. Baikal skullcap is … Huang, W. M., Yan, J., and Xu, J. New York, NY: CRC Press LLC. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. Ye, F., Jiang, S., Volshonok, H., Wu, J., and Zhang, D. Y. Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. Baikal skullcap is used to treat respiratory infections, hay fever, and fever. View abstract. 1-8-2007;245(1-2):269-274. 11-28-2000;160(2):219-228. Food Chem Toxicol. Planta Med 2001;67(4):331-334. Research Breakdown on Scutellaria baicalensis, https://examine.com/supplements/scutellaria-baicalensis/. BMC.Complement Altern Med 2006;6:27. Vopr.Onkol. Zhang, X. W., Li, W. F., Li, W. W., Ren, K. H., Fan, C. M., Chen, Y. Y., and Shen, Y. L. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Planta Med 2011;77(5):455-460. 7-1-2005;382(1-2):71-75. 11-12-2009;126(2):320-331. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Monitor your blood sugar closely. 1-27-2011;133(2):634-641. Eksp.Klin Farmakol. Anticancer Res 2007;27(1A):117-125. View abstract. American and Chinese skullcap are flowering plants commonly used in natural medicine to treat a variety of conditions, including insomnia, inflammation, … Pulm.Pharmacol Ther 2010;23(5):411-419. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. 1997;57(1):63-67. Yao Xue.Xue.Bao. Ann N Y Acad Sci 2007;1095:521-526. You, C. L., Su, P. Q., and Zhou, X. X. J Agric Food Chem 4-23-2008;56(8):2838-2845. Zhou, J., Qu, F., Burrows, E., Yu, Y., and Nan, R. Acupuncture can improve absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats. Ceska.Slov.Farm. View abstract. View abstract. Chalasani N, Vuppalanchi R, Navarro V, et al. View abstract. View abstract. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. At Examine.com, our incentives line up with yours — getting unbiased information. Cardiovasc.Res 2-1-2011;89(2):426-435. 4.6 out of 5 stars 44. Zeng H.Y and Praveen K.S. Metformin (Glucophage) is used to help decrease blood sugar. View abstract. A food supplement to support your health. Safest Tea Kettle Material? Treatment of acute bronchiolitis with Chinese herbs. Scutellaria baicalensis Scutellaria baicalensis (Chinese Skullcap) is a traditional chinese medicine for the purposes of cardiovascular and cognitive health as well as longevity. Journal of Dietary Supplements 2010;7:253. Chen et C. Ling and Scutellaria baicalensis Georgi. View abstract. The active ingredient in Baikal skullcap, baicalin, is used in combination with shung hua (ephedra) to treat upper respiratory tract infections. 1990;36(5):602-607. Am J Chin Med 2001;29(1):69-81. Kimura, Y. and Sumiyoshi, M. Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. View abstract. Wang, H. W., Lin, C. P., Chiu, J. H., Chow, K. C., Kuo, K. T., Lin, C. S., and Wang, L. S. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. Monitor your blood sugar closely. However, there are concerns that this combination product might cause liver problems in some people. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. Arch Dis Child 1993;68:468-71. 1987;33(2):80-84. Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. Chinese Skullcap. Some medications are changed and broken down by the liver. Hu, Z., Yang, X., Ho, P. C., Chan, S. Y., Heng, P. W., Chan, E., Duan, W., Koh, H. L., and Zhou, S. Herb-drug interactions: a literature review. Although there is a lack of human evidence to support the optimal dosage of scutellaria baicalensis for supplementation purposes, the doses that appear optimal in rat and mouse models suggest that an oral dose of around 500mg of the root extract should be efficacious. For centuries, the Chinese skullcap has remained one of the most vital medicinal plants in Chinese herbal treatments and medicine. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. View abstract. Pharmacol Biochem Behav 2009;92(4):642-648. Tseng, Y. P., Wu, Y. C., Leu, Y. L., Yeh, S. F., and Chou, C. K. Scutellariae radix suppresses hepatitis B virus production in human hepatoma cells. The Chinese have used the herb in traditional medicine for over 2000 years. J Ethnopharmacol 2005;98:295-300. View abstract. View abstract. Gabrielska, J., Oszmianski, J., Zylka, R., and Komorowska, M. Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Altavilla D, Squadrito F, Bitto A, et al. There have been reports of fever and lung inflammation in people who took Baikal skullcap. BioPure Chinese Skullcap, Scutellaria baicalensis, also known as Huang-Qin, or Baikal Skullcap, is an herb in the Lamiaceae (mint) family. Baikal skullcap might also lower blood sugar. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. View abstract. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Skullcap gets its name from its blue to purplish-pink flowers that have a shape resembling a medieval knight’s helmet. Pharmacogenomics of human OATP transporters. Am J Chin Med 2008;36(3):517-540. Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy. Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. Shim K.S, Kim S.N, Kim M.H, and et al. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. It is also said to be an effective remedy for severe diseases like cancer as it is said to have cancer-fighting properties. The dose of your metformin (Glucophage) might need to be changed. View abstract. 2006;63(2):95-96. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. View abstract. Zhongguo Zhong.Yao Za Zhi 2010;35(6):682-685. Fighting bacteria, viruses and fungi. View abstract. View abstract. Not enough is known about the safety of Baikal skullcap in children when used long-term. 5-24-2006;105(3):346-351. View abstract. Int J Cancer 5-1-2007;120(9):2019-2027. Interdiscip.Sci 2010;2(2):151-156. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. According to the International Journal of Molecular Medicine, Chinese skullcap has been known to induce apoptosis (sudden cell death), in cancerous cells and is used for the treatment of cancer. Int J Mol Med 2004;14(4):627-632. View abstract. View abstract. Zhongguo Ying.Yong.Sheng Li Xue.Za Zhi 2009;25(3):344-348. Visit the FDA MedWatch website or call 1-800-FDA-1088. View abstract. View abstract. This action is found to be caused by a compound called scutellarein in the herb. Ann Intern Med 2012;156:857-60. Wiad.Lek. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., and Kwon, T. K. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. It is, by itself, strongly antiviral … Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. J Cell Biochem 12-15-2010;111(6):1629-1641. Indian J Med Res 2008;127(6):610-615. 2010;48(5):1202-1209. View abstract. Morgan SL, Baggott JE, Moreland L, et al. Clin Pharmacol Ther 2007;82:726-33. Afr J Tradit.Complement Altern Med 2010;7(4):339-349. Fitoterapia 2009;80(7):448-452. The Cherokee used skullcap to stimulate menstruation, relieve breast pain, and to encourage the expulsion of the placenta after childbirth. View abstract. View abstract. J Dent Res 1982;61(9):1103-1106. 11-15-2009;171(1-3):508-513. Ren S, Cao D., Yang J, and et al. This might increase the side effects of some medications. Int J Oncol. 6-29-2001;500(1-2):52-55. Biull.Eksp.Biol Med 1999;128(9):327-329. Yuan Y., Liu Y.J, Luo Y.J, and et al. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Alcohol can cause sleepiness and drowsiness. Shang, Y. Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Baikal skullcap might have the same effects as the female hormone estrogen. Armstrong, T. S. and Gilbert, M. R. Use of complementary and alternative medical therapy by patients with primary brain tumors. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Pharmacology 2006;77(2):71-77. Park, K. I., Park, H. S., Kang, S. R., Nagappan, A., Lee, D. H., Kim, J. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. Chinese skullcap (Scutellaria baicalensis) is an herb commonly used in traditional Chinese medicine. Z., Yang, L. H., Guan, Y., and Shi, J. S. [Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy]. Pharmacol.Res. Mol Nutr Food Res 2008;52(11):1349-1357. View abstract. View abstract. Chang, W. H., Chen, C. H., and Lu, F. J. View abstract. View abstract. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. to see the full set of research information and references for Scutellaria baicalensis. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it. Chinese Skullcap (4000mg) 365 Capsules, 12 Months Supply, by vytox, Vegetarian 2.9 out of 5 stars 2 £19.99£19.99 (£13.69/kg) J Altern Complement Med 2002;8(5):567-572. In a traditional way, Chinese skullcap roots are used to treat … Clin Pharmacol Ther 2007;83:471-6. Chen, L. G., Hung, L. Y., Tsai, K. W., Pan, Y. S., Tsai, Y. D., Li, Y. Ye, F., Xui, L., Yi, J., Zhang, W., and Zhang, D. Y. Anticancer activity of Scutellaria baicalensis and its potential mechanism. It is a house of multiple medicinal compounds, especially flavonoids which have diverse anti-oxidant and anti-inflammatory properties. In the summer, small, blue flowers present themselves as a shape that resembles a helmet or cap. Mol Biol (Mosk) 2009;43(6):1082-1087. Drug Metab Dispos 2005;33:537-46. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol. View abstract. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. 2nd ed. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. Wei, L., Lu, N., Dai, Q., Rong, J., Chen, Y., Li, Z., You, Q., and Guo, Q. View abstract. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. Baikal skullcap is also sometimes applied to the skin for psoriasis. Lu, H. F., Hsueh, S. C., Ho, Y. T., Kao, M. C., Yang, J. S., Chiu, T. H., Huamg, S. Y., Lin, C. C., and Chung, J. G. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Lee, B. S., Shim, S. M., Heo, J., Pae, H. O., Seo, B. Y., Han, S. Y., Sohn, D. H., Jang, S. I., and Chung, H. T. Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Ceska.Slov.Farm. Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. View abstract. View abstract. Stop using Baikal skullcap at least 2 weeks before a scheduled surgery. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Anesth Analg 2003;97:1724-9. View abstract. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. View abstract. Baikal skullcap might have some of the same effects as estrogen. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Krskova, Z., Martin, J., Pec, J., and Dusek, J. View abstract. J Ethnopharmacol. Zhongguo Zhong.Yao Za Zhi 2009;34(21):2803-2807. View abstract. 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