Posts about Symptoms written by Sharon Williams. It shouldn’t matter whether the evidence comes from unenhanced brain MR images, gadolinium detected in biopsy specimens, prolonged gadolinium excretion in urine specimens, or other testing methods. ( Log Out / As a possible additional marker for damage of small fibers, the appearance of terminal axonal swellings (TASs) was assessed. Reports of possible clinical symptoms experienced by patients after a contrast-enhanced MRI have been published. Updated Gadolinium Retention test result information is also presented. Skin that may feel \"woody\" and develop an orange-peel appearance and darkening (excess pigmentation) 4. Nephrogenic systemic fibrosis can begin days to months after exposure to gadolinium-containing contrast. So the good news is that there are relatively few commercial uses for this dangerous metal and its compounds (1). The study involved 6 groups of 8 mice that were intravenously injected with one dose (1 mmol/kg body weight) of either a macrocyclic GBCA (gadoteridol, gadoterate meglumine, gadobutrol), a linear GBCA (gadodiamide or gadobenate dimeglumine), or saline. They found a significant reduction of IEFND in the footpad of mice for all GBCAs tested compared with the control group. Mai 2018 2. You may have to undergo an additional dialysis if all the gadolinium was not removed from your body, in which case gadolinium poisoning will occur on and around the access site. www.GadoliniumToxicity.com. As we have said many times before, Gadolinium Toxicity is a “disease of degrees” which we believe causes a disease process of varying severity with NSF likely being the most severe manifestation of it, but there is no reason to think it will be the only one. Interestingly, as you will see in my letter, many symptoms of SFN are the same as the clinical symptoms associated with nephrogenic systemic fibrosis (NSF), which makes sense to me since the cause is the same. Isn’t it logical to think that lesser amounts of retained gadolinium could cause similar but perhaps less severe damage to various body systems in almost every patient who retains it? Nephrogenic systemic fibrosis can begin days to months after exposure to gadolinium-containing contrast. Coauthor of The Lighthouse Project For more information about NSF, GBCAs, and Gadolinium, please see the Background section of our website. Some signs and symptoms of nephrogenic systemic fibrosis may include: 1. The development of symptoms such as headaches, bone/joint pain and skin changes appear to occur earlier, with typical onset times reported between hours and days post-contrast-enhanced MRI [ 24, 25 ]. With all of that published evidence of gadolinium’s toxic effects, I don’t believe it should come as a surprise to anyone that patients are reporting a wide range of symptoms after their MRIs with a gadolinium-based contrast agent – if anything, it seems it should be expected. Small fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ-fibers and unmyelinated C-fibers, and it is typically associated with burning pain in the lower arms and legs. I believe many symptoms of gadolinium toxicity can be explained by Gd-induced small fiber neuropathy (SFN) and long-standing neuropathic pain. What difference does a name make? Absence of potential gadolinium toxicity symptoms following 22,897 gadoteric acid (Dotarem®) examinations, including 3,209 performed on renally insufficient individuals Eur Radiol. Since early 2014, medical experts from around the world have slowly come to recognize that all patients who have MRIs with a GBCA likely retain an unknown amount of gadolinium in their brain, bones, skin, and other tissues. Toxicity is rarely associated with Gd due to its poor gastrointestinal absorption (it is suspected that very little Gd is absorbed from the gastrointestinal tract (<0.05%). Several of the papers cited by Marckmann were referenced in my 2012 letter to the FDA to make my point that gadolinium retention could happen to ALL patients and they could be adversely affected by it. noted in their 2009 paper, “A Primer on gadolinium chemistry”, one of the reasons why Gd3+ (gadolinium) is so toxic in biological systems, is because its ionic radius nearly equals that of Ca2+ (calcium), and because of that, gadolinium can compete with calcium in all biological systems that require Ca2+ for proper function. The authors noted that the cause of SFN remains unknown in up to 50% of cases. Even though impaired kidney function did not cause NSF, the focus remained on the “N” or nephrogenic part of NSF. The bad news is that its main commercial use … They said that the “unusual clinical presentation and nonspecific histology means that it may be very hard to come to the NSF diagnosis in some patients. Information and conclusions presented here should not be interpreted as medical advice. Particularly as this experiment has been done on 300-400 million people who weren't aware of this, they were only warned it may retain if their kidney was damaged and it may then have fatal consequences in that case (NSF). Symptoms often develop within a month or so of the MRI. Their self-reported symptoms have recently been published. Gadolinium (Gd) Result 1.2 Reference Interval < 0.8 ... Gadolinium has no known biological role in humans. As more research was performed and more patient data was gathered, the evidence and understanding of what retained gadolinium can do to the human body has increased significantly. A healthy human body should naturally eliminate Gadolinium through the kidneys. Swelling and tightening of the skin 2. Patients with normal kidney function were being overlooked; however, they were not unaffected by retained gadolinium from GBCAs. Symptoms of Gadolinium Toxicity/Gadolinium Deposition Disease. In 1997, when a group of patients on dialysis developed what appeared to be a new skin disorder, it was called Nephrogenic Fibrosing Dermopathy (NFD). An expansion of described symptoms for GDD. Intraepidermal nerve fiber density (IEFND) was calculated, and the median number of terminal axonal swellings (TASs) per IEFND was determined. Interestingly, as you will see in my letter, many symptoms of SFN are the same as the clinical symptoms associated with nephrogenic systemic fibrosis (NSF), which makes sense to me since the cause is the same. The reason for making my letter available to the public now is to inform doctors, researchers, and affected patients about gadolinium-related facts that do not seem to be widely recognized. However, I am concerned that the diagnostic criteria for GDD could result in some patients who have been affected by retained gadolinium not being recognized and properly diagnosed. The updated graphs show an even stronger pattern of Gadolinium urine levels based on the number of months since the participant’s last Contrast MRI. I believe the “N” in NSF sent us down the wrong path and it has caused many patients who have retained gadolinium not to be properly diagnosed simply because they did not have impaired kidney function or NSF-like skin changes. If that was the case in full-blown NSF, when the patient likely retained a lot more gadolinium, think how retaining less gadolinium might impact the clinical picture of patients with normal or near-normal renal function. Our only advice is to consider symptom relief carefully, and do not try to be the hero who says “I … https://gdtoxicity.files.wordpress.com/2016/10/swilliams-2012fda-letter-gdtoxicity1.pdf, Tags: Gadolinium Retention, Gadolinium Toxicity, Gadolinium-Based Contrast Agents, GBCAs, NSF. The symptoms of Gadolinium Toxicity can include: Pain in the arms and legs Any bones can have severe point pain, but rib pain is quite distinctive for the disease. However, until this study, it was unknown whether GBCAs induce toxic effects on the cellular function of human neurons. Second, the symptoms experienced by the patient after GBCA administration must be new, and not preexisting. As you will see, Gadolinium Toxicity is not a new problem, but just one that should be recognized for the potential harm it can cause to everyone who retains gadolinium from the gadolinium-based contrast agents administered for MRIs. Can Symptoms of Gadolinium Toxicity be explained? Allgemein / Gadolinium. “For all agents, the magnitude of the toxicity increases with concentration.” (more…), May 19, 2018 3:57 pm / 2 Comments on Head Pain is a diagnostic feature of Gadolinium Deposition Disease. The symptoms in Gadolinium deposition disease are similar to nephrogenic systemic fibrosis (NSF) but are less severe. A preclinical study by Bower et al. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2853020&tool=pmcentrez&rendertype=abstract, Williams, S. (2012). A 2009 paper by Marckmann and Skov, “Nephrogenic Systemic Fibrosis: Clinical Picture and Treatment”, provides some important insight into other aspects of NSF beyond just the expected biopsy findings. Materials and methods: This HIPAA-compliant, IRB-approved study consisted of an anonymous online survey of patients who believe that they suffer from gadolinium toxicity. Home » Advocacy » Gadolinium Toxicity: If not NSF, then what is it? Gadolinium Deposition Disease. They can also have chronic symptoms for years. Four weeks after injection, the mice were euthanized, and footpads were assessed using immunofluorescence staining. At the beginning, that made sense since the problem only had been seen in patients with end-stage renal disease (ESRD). Arising in early stage (early on after GBCA): Many terms have been used for this: mental confusion sounds more scientific, but brain fog gets the point across well and succinctly. These two properties provide differentiating features for this entity. Symptoms typically decrease in intensity over time, but many patients report that symptoms can last for years after the scan. Die Symptome einer Gadolinium-Vergiftung sind vielfältig und häufig schwer zu deuten bzw. In 2006, nine years after NSF/NFD was first diagnosed, the connection was made between NSF and gadolinium-based contrast agents (GBCAs) administered for MRIs. Symptoms. Retrieved from http://ard.bmj.com/content/69/11/1895.full.pdf, Marckmann, P., & Skov, L. (2009). Gadolinium deposition disease refers to situations in which a person has normal or adequate renal function but develops persistent and/or painful symptoms anywhere from a few hours to several weeks after being injected with a gadolinium contrast agent. First, symptoms of GDD must start within minutes to one month after administration of a gadolinium-based contrast agent (GBCA). Symptoms of Gadolinium Toxicity: Can their cause be explained? This symptom complex should be expected. With the current status of understanding gadolinium toxicity by the medical community, there is no known or verified methods to know with absolute certainty if you are gadolinium toxic or have symptoms that are caused by the element. Given that Gd has been shown to induce mitochondrial toxicity, interfere with ion channels, create neuronal hyperexcitability, and affect inflammatory processes, could Gd be affecting not only the part of the brain that controls many processes, but also peripheral and autonomic nerve endings, as well as dorsal root ganglia, to produce the many and varied symptoms that patients are experiencing? I believe that resulted in a gross underreporting of the health problems being caused by retained gadolinium. Change ), You are commenting using your Twitter account. Information and conclusions presented here should not be interpreted as medical advice. Purpose: This study aims to describe the self-reporting symptoms experienced by individuals with self-reported normal renal function after gadolinium based contrast agent (GBCA) administration. They found a significant increase of TAS/IEFND for the linear GBCAs, whereas only a “trend without significance” was found for the macrocyclic agents. shedding light on the effects of retained gadolinium from Contrast MRI, September 22, 2020 12:19 pm / Leave a comment. (A pdf of this Editorial is available for download). As Marckmann pointed out, “supporting evidence of the causal relationship between GBCA and NSF comes from ex vivo and animal studies demonstrating that Gd-salts and some GBCAs cause histologic and clinical effects resembling what is seen in NSF“. This study provides the first definitive evidence that GBCAs induce mitochondrial toxicity and cell death in cultured human neurons. 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